In this PSA from the 80’s, Johnny Depp and fellow cast-members of the TV series 21 Jump Street demonstrate that it’s cool to not do drugs, warning kids that they “can really mess you up”. Now the stars of the big screen version of 21 Jump Street, which opens in theaters this weekend, warn us of the dangers of “fictional drugs” in this Funny or Die throwback video. Channing Tatum, Jonah Hill and Rob Riggel, who play undercover cops investigating “HFS,” a made-up synthetic drug, raise awareness about other fictional hazards, such as: “shooting up air freshener, or glading”, “belgian taffy,” “Blink-182 CDs,” or just “good old-fashioned Jamie Lee Curtis.”

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